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The rapid spread of a new variant of coronavirus has been blamed for the introduction of strict tier four mixing rules for millions of people, harsher restrictions on mixing at Christmas in England, Scotland and Wales, and other countries placing the UK on a travel ban.

So how has it gone from being non-existent to the most common form of the virus in parts of England in a matter of months?

The government’s advisers on new infections now say they have “high” confidence that it is more able to transmit than other variants.

All the work is at an early stage, contains huge uncertainties and a long list of unanswered questions.

As I’ve written before, viruses mutate all the time and it’s vital to keep a laser focus on whether the virus’ behaviour is changing.

Why is this variant causing concern?

Three things are coming together that mean it is attracting attention:

  • It is rapidly replacing other versions of the virus
  • It has mutations that affect part of the virus likely to be important
  • Some of those mutations have already been shown in the lab to increase the ability of the virus to infect cells

All of these come together to build a case for a virus that can spread more easily.

However, we do not have absolute certainty. New strains can become more common simply by being in the right place at the right time – such as London, which had only tier two restrictions until recently.

But already the justification for tier four restrictions is in part to reduce the spread of the variant.

“Laboratory experiments are required, but do you want to wait weeks or months [to see the results and take action to limit the spread]? Probably not in these circumstances,” Prof Nick Loman, from the Covid-19 Genomics UK Consortium, told me.

How much faster is it spreading?

It was first detected in September. In November around a quarter of cases in London were the new variant. This reached nearly two-thirds of cases in mid-December.

You can see how the variant has come to dominate the results of testing in some centres such as the Milton Keynes Lighthouse Laboratory.

Mathematicians have been running the numbers on the spread of different variants in an attempt to calculate how much of an edge this one might have.

But teasing apart what is due to people’s behaviour and what is due to the virus is hard.

The figure mentioned by Prime Minister Boris Johnson was that the variant may be up to 70% more transmissible. He said this may be increasing the R number – which indicates if an epidemic is growing or shrinking – by 0.4.

That 70% number appeared in a presentation by Dr Erik Volz, from Imperial College London, on Friday.

During the talk he said: “It is really too early to tell… but from what we see so far it is growing very quickly, it is growing faster than [a previous variant] ever grew, but it is important to keep an eye on this.”

There is no “nailed on” figure for how much more infectious the variant may be. Scientists, whose work is not yet public, have told me figures both much higher and much lower than 70%.

But there remain questions about whether it is any more infectious at all.

“The amount of evidence in the public domain is woefully inadequate to draw strong or firm opinions on whether the virus has truly increased transmission,” said Prof Jonathan Ball, a virologist at the University of Nottingham.

How far has it spread?

It is thought the variant either emerged in a patient in the UK or has been imported from a country with a lower ability to monitor coronavirus mutations.

The variant can be found across the UK, except Northern Ireland, but it is heavily concentrated in London, the South East and eastern England. Cases elsewhere in the country do not seem to have taken off.

Data from Nextstrain, which has been monitoring the genetic codes of the viral samples around the world, suggest cases in Denmark and Australia have come from the UK. The Netherlands has also reported cases.

A similar variant that has emerged in South Africa shares some of the same mutations, but appears to be unrelated to this one.

Has this happened before?

Yes.

The virus that was first detected in Wuhan, China, is not the same one you will find in most corners of the world.

The D614G mutation emerged in Europe in February and became the globally dominant form of the virus.

Another, called A222V, spread across Europe and was linked to people’s summer holidays in Spain.

What do we know about the new mutations?

An initial analysis of the new variant has been published and identifies 17 potentially important alterations.

There have been changes to the spike protein – this is the key the virus uses to unlock the doorway to our body’s cells.

One mutation called N501Y alters the most important part of the spike, known as the “receptor-binding domain”.

This is where the spike makes first contact with the surface of our body’s cells. Any changes that make it easier for the virus to get inside are likely to give it an edge.

“It looks and smells like an important adaptation,” said Prof Loman.

The other mutation – a H69/V70 deletion, in which a small part of the spike is removed – has emerged several times before, including famously in infected mink.

Work by Prof Ravi Gupta at the University of Cambridge has suggested this mutation increases infectivity two-fold in lab experiments.

Studies by the same group suggest the deletion makes antibodies from the blood of survivors less effective at attacking the virus.

Prof Gupta told me: “It is rapidly increasing, that’s what’s worried government, we are worried, most scientists are worried.”

Where has it come from?

The variant is unusually highly mutated.

The most likely explanation is the variant has emerged in a patient with a weakened immune system that was unable to beat the virus.

Instead their body became a breeding ground for the virus to mutate.

Does it make the infection more deadly?

There is no evidence to suggest that it does, although this will need to be monitored.

However, just increasing transmission would be enough to cause problems for hospitals.

If the new variant means more people are infected more quickly, that would in turn lead to more people needing hospital treatment.

Will the vaccines work against the new variant?

Almost certainly yes, or at least for now.

All three leading vaccines develop an immune response against the existing spike, which is why the question comes up.

Vaccines train the immune system to attack several different parts of the virus, so even though part of the spike has mutated, the vaccines should still work.

“But if we let it add more mutations, then you start worrying,” said Prof Gupta.

“This virus is potentially on a pathway for vaccine escape, it has taken the first couple of steps towards that.”

Vaccine escape happens when the virus changes so it dodges the full effect of the vaccine and continues to infect people.

This may be the most concerning element of what is happening with the virus.

This variant is just the latest to show the virus is continuing to adapt as it infects more and more of us.

A presentation by Prof David Robertson, from the University of Glasgow on Friday, concluded: “The virus will probably be able to generate vaccine escape mutants.”

That would put us in a position similar to flu, where the vaccines need to be regularly updated. Fortunately the vaccines we have are very easy to tweak.

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Foreign

Israel’s War On Gaza: List of Key Events, Day 101

Published

3 years ago

on

15th January 2024

By

Israel's war on Gaza: List of key events, day 101 | Israel War on Gaza News | Al Jazeera

Dozens of Palestinians killed in overnight Israeli strikes in central and south Gaza as Red Sea tensions rise.

Here’s how things stand on Monday, January 15, 2024:

Latest updates and human impact

  • Israeli attacks continue unabated overnight killing and wounding dozens of civilians in central and southern Gaza. At least 22 people were killed and a large number injured as a result of Israeli forces targeting al-Thalatheni Street in the central Gaza Strip.
  • Yemen’s Houthi rebels fired an antiship cruise missile toward an American destroyer in the Red Sea, which was shot down by a US fighter jet, announced US Central Command (CENTCOM) on X.
  • This was the first US-acknowledged Houthi attack since the US strikes on Yemen on Friday.
  • Hamas released a 37-second video showing three Israeli captives held in Gaza on Sunday, saying they would reveal the fate of the captives on Monday and urging the Israeli government to stop the offensive.
  • The Israeli military says it has shifted to a new phase of the war focused on the southern end of Gaza, where almost 2 million internally displaced Palestinians are running out of safe spaces to shelter.
  • The Gaza Ministry of Health has said almost 24,000 people have been killed in the Israeli offensive. More than 60,000 people have been wounded in 100 days of war.

Diplomacy

  • Israeli Prime Minister Benjamin Netanyahu said on Sunday that his country will pursue its war against Hamas until victory and will not be stopped by anyone, including the International Court of Justice (ICJ).
  • The White House said on Sunday that “it’s the right time” for Israel to scale back its military offensive in the Gaza Strip.
  • Egypt’s State Information Service (SIS) said in a statement on Sunday that one of the biggest obstacles to the timely delivery of sufficient aid to Gaza was Israeli inspection of the aid. The statement came after Israel blamed Cairo for the delay in aid delivery to Gaza during its defence at the ICJ.
  • US Secretary of State Antony Blinken posted on X on Monday, calling for the release of the remaining captives held in Gaza on the 100th day since they were taken by Hamas. He did not mention the Palestinian casualties.
  • Australia’s Foreign Minister Penny Wong, who described herself as a “friend of Israel” to the press, will travel to Jordan, Israel, the occupied Palestinian Territories and the United Arab Emirates this week, her office said on Monday.

West Bank raids and violence

  • Israeli forces arrested 25 students staging a sit-in in protest against high tuition fees at An-Najah University in Nablus. Al Jazeera’s Hamdah Salhut reported that the protesting students received a text message from Israeli forces telling them to “surrender now”.
  • Israeli forces have reportedly raided the family home of Nael al-Barghouti, the longest-serving Palestinian prisoner, in the village of Kobar, in Ramallah, in the occupied West Bank.
  • The Israeli army said on Friday that it killed three Palestinian men who infiltrated a West Bank settlement and fired upon soldiers.
  • The Israeli military killed two Palestinians after accusing them of ramming their car through a checkpoint near Hebron.
  • Local sources reported that Israeli forces bulldozed two Palestinian-owned houses during a Sunday midnight raid in the city of Qalqilya, Palestinian news agency Wafa reported.
  • Armed Israeli settlers broke into the village of Burin, south of Nablus, and attacked Palestinian residents’ houses and properties after midnight on Sunday, Wafa reported.
  • “Violent raids and arrests have become part of the fabric of daily life in the occupied West Bank,” Al Jazeera’s Mohammed Jamjoom, reporting from Ramallah in the occupied West Bank, said. At least 347 Palestinians have been killed and thousands have been arrested since October 7.

 

SOURCE: AL JAZEERA AND NEWS AGENCIES
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Foreign

Hamas Says Will Kill Hostages if Israeli Attacks On Gaza Civilians Continue

Published

3 years ago

on

10th October 2023

By

Flames and smoke billow during Israeli attacks against Gaza on October 9, 2023

Human Rights Watch terms Israeli Defence Minister Yoav Gallant’s call for a ‘complete siege’ on Gaza a ‘war crime’.

The Hamas movement has threatened to kill an Israeli hostage every time Israel bombs a Palestinian home without warning as Israel mobilised some 300,000 reservists and imposed a total blockade of the Gaza Strip, denying the enclave’s millions of residents access to food, water and fuel.

The warning from Hamas came on Monday as the death toll from the armed group’s surprise weekend attack climbed to 900 in Israel and revenge attacks by Israeli forces on the besieged Gaza Strip killed more than 700 people and left some 3,700 others wounded.

Residential apartment blocks, hospitals, schools and a mosque have been among the sites attacked by Israeli fighter jets, artillery and drones, according to media reports and witnesses.

Hamas spokesperson Abu Ubaida issued the threat to kill Israelis from the dozens held captive by the armed group. He said an Israeli hostage would be killed for every Israeli bombing of a civilian house without warning.

Israeli Foreign Minister Eli Cohen said more than 100 people were taken captive by Hamas during the deadly cross-border incursion over the weekend.

As Israeli forces conducted intense retaliatory attacks on Gaza on Monday, Israel’s Defence Minister Yoav Gallant drew international condemnation by announcing a total blockade of the densely populated and besieged enclave, which is home to 2.3 million people.

Gallant said Israel would impose a “complete siege” on Gaza. “No electricity, no food, no water, no gas – it’s all closed.”

United Nations Secretary-General Antonio Guterres said he was “deeply distressed” by the siege announcement and warned that Gaza’s already dire humanitarian situation will now “only deteriorate exponentially”.

A mourner carries the body of Palestinian boy Saad Lubbad, who health officials said was killed in Israeli strikes, during his funeral in Rafah, in the southern Gaza Strip, October 9, 2023. REUTERS/Ibraheem Abu Mustafa
A mourner carries the body of Palestinian boy Saad Lubbad, who health officials said was killed in an Israeli attack, during his funeral in Rafah, in the southern Gaza Strip, on October 9, 2023 [Ibraheem Abu Mustafa/Reuters]

Guterres also said some 137,000 people were taking shelter with the UN Relief and Works Agency for Palestinian Refugees (UNRWA) at schools across Gaza.

UNRWA said on Tuesday that almost 190,000 people have been displaced in Gaza amid the Israeli attacks and the figure is expected to grow further as the violence intensifies.

Nearly half a million people have also not received food rations this week in Gaza as UN food distribution centres have been forced to remain closed amid the Israeli onslaught, UNRWA said.

Human Rights Watch said Israel’s total blockade on the necessities of life for everyday people in Gaza was a war crime.

“Defense Minister Gallant’s statements are abhorrent,” Omar Shakir, Israel and Palestine director at Human Rights Watch, said in a statement.

“Depriving the population in an occupied territory of food and electricity is collective punishment, which is a war crime, as is using starvation as a weapon of war. The International Criminal Court should take note of this call to commit a war crime,” he said.

Shakir also condemned the threat by Hamas to kill hostages, warning that such action was also a war crime.

“All hostages should be safely released to their families,” he said.

On the diplomatic front, Egyptian President Abdel Fattah el-Sisi and his Turkish counterpart Recep Tayyip Erdogan called on Hamas and Israel to immediately end violence and protect civilians, the Egyptian presidency said.

Erdogan urged Israel against “indiscriminately” attacking civilians and delivered measured criticism of Hamas, urging both sides to respect the “ethics” of war.

The United Kingdom, French, German, Italian and US governments issued a joint statement on Monday recognising the “legitimate aspirations” of the Palestinian people and supporting equal measures of justice and freedom for Israelis and Palestinians alike.

INTERACTIVE_DEATH_TOLL_INJURED_ISRAEL_PALESTINE_OCT10_2023_0415
They said they would remain “united and coordinated” to ensure Israel can defend itself.

But the prospect that fighting could spread also alarmed the region and the world.

Lebanese armed group Hezbollah fired rockets into northern Israel in response to at least three of its members being killed in Israeli shelling of Lebanon.

Israel said one of its deputy commanders was also killed in an earlier cross-border raid from Lebanon.

SOURCE: AL JAZEERA AND NEWS AGENCIES

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Foreign

Western Leaders Accused of Hypocrisy Over Response To Palestine, Ukraine

Published

3 years ago

on

10th October 2023

By

US President Joe Biden holds a bilateral meeting with Israeli Prime Minister Benjamin Netanyahu on the sidelines of the 78th United Nations General Assembly in New York City, the US, September 20, 2023

Social media users, including journalists and observers, are calling out what they call a ‘double standard’.

After Saturday’s surprise attack by the Palestinian group Hamas on Israel, Ukrainian President Volodymyr Zelenskyy took to the social media platform X to offer “condolences go out to everyone who lost relatives or close ones in the terrorist attack”.

He also stated, “Israel’s right to self-defence is unquestionable.”

Many world leaders, including US President Joe Biden and UK Prime Minister Rishi Sunak, shared similar sentiments.

European Commission President Ursula von der Leyen stated, “Israel has the right to defend itself – today and in the days to come. The European Union stands with Israel.”

Accusations of Western ‘double standards’

Some social media users have criticised these statements, saying they highlight a double standard.

Ukraine’s right to defend itself is praised by most international leaders while Russia’s invasion is condemned, but commentators said the same cannot be said about Israel’s occupation of the West Bank and Gaza.

Aaron Bastani, a leftist British journalist, said on X that there’s a “clear double standard in endorsing terrorism against civilian targets in Ukraine … and condemning it by Palestinians”.

Many users said Western diplomats and media support the Ukrainians who defend their land, but label the Palestinians fighting against Israel as “terrorists”.

https://twitter.com/KhaledBeydoun/status/1710787817415082349?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1710787817415082349%7Ctwgr%5E6acf829869e993177f32aa38aa48c02f38cb7f61%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fwww.aljazeera.com%2Fnews%2F2023%2F10%2F9%2Fwestern-leaders-accused-of-hypocrisy-over-response-to-palestine-ukraine

An illustration of a woman’s face, in which one eye is closed beside a Palestinian flag, and one eye open beside a Ukrainian flag, has been regularly shared as a symbol of the West’s alleged double standards in how the two conflicts are viewed.

https://twitter.com/OnlinePalEng/status/1710994682883273172?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1710994682883273172%7Ctwgr%5E6acf829869e993177f32aa38aa48c02f38cb7f61%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fwww.aljazeera.com%2Fnews%2F2023%2F10%2F9%2Fwestern-leaders-accused-of-hypocrisy-over-response-to-palestine-ukraine

Clips also emerged on social media from a CNN interview with Mustafa Barghouti, the general secretary of the Palestinian National Initiative, in which he posed the rhetorical question, “Why does the United States support Ukraine in fighting occupation – while here they support the occupier, who continues to occupy us?”

It is not the first time Western nations have been accused of double standards in their stance on the Ukraine war.

Earlier in the year, Amnesty International published a report highlighting the West’s “double standards” on global human rights.

Agnes Callamard, Amnesty’s secretary-general, told Al Jazeera at the time that the occupation of Palestinian territory was a “particularly important one”.

“Without making any comparison between Russia’s aggression and Israel … it is clear the Palestinian people are under a regime of oppression – a regime of occupation and a regime of apartheid,” Callamard told Al Jazeera.

Over the last three days, X users recirculated earlier statements calling out what they called Western hypocrisy, sharing video by the Irish lawmaker Richard Boyd Barrett from March 2022 in which he berated the Irish government’s double standards regarding Ukraine and Palestine:

“You’re happy to use the most strong and robust language to describe the crimes against humanity of [Russian President] Vladimir Putin, but you will not use the same strength of language when it comes to describing Israel’s treatment of the Palestinians.”

Barrett on Sunday again called out what he described as “shocking double standards of Western leaders supporting Ukraine resistance but condemning Palestinian[s].”

Meanwhile, others warned against comparing conflicts.

https://twitter.com/denfordauthor/status/1710993737738768607?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1710993737738768607%7Ctwgr%5E6acf829869e993177f32aa38aa48c02f38cb7f61%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fwww.aljazeera.com%2Fnews%2F2023%2F10%2F9%2Fwestern-leaders-accused-of-hypocrisy-over-response-to-palestine-ukraine

And some cautioned that Hamas and the Palestinians should not be seen as one and the same.

Ukrainian footballer Oleksandr Zinchenko, who plays for Arsenal, posted on Instagram, stating he “stands with Israel”.

Zinchenko has been a vocal supporter of his home country in its ongoing defence against Russia, and he participated in a Game4Ukraine charity match in London earlier this year to raise money for Ukraine.

After online backlash, with some questioning an alleged double standard in his support of Israel, the footballer removed the post and switched his social media account to private.

Several people claimed that Zinchenko’s football club, in not responding to his comments, was guilty of hypocrisy after they had distanced themselves from former player Mesut Ozil’s comments in 2019 over alleged human rights abuses against Uighur Muslims in China.

SOURCE: AL JAZEERA
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