Investigators are conducting DNA tests after human remains were found near the site of the powerful blast.
The home of a possible person of interest was searched on Saturday in Nashville’s suburb of Antioch.
The blast injured three people and disrupted communications systems in Tennessee and four other states.
No motive has yet been established for the explosion in the state of Tennessee, and no-one has yet said they were behind it.
Meanwhile, businesses and TV personalities have offered more than $300,000 (£224,000) to catch those responsible.
What are the latest developments?
Investigators now believe that the blast was likely the result of a suicide bombing, according to two law enforcement sources cited by CNN.
CNN is also quoting an FBI official as saying that agents are not looking for another suspect after the human remains were found.
CBS News says the leading theory now is that the subject may have been killed in the blast.
#Nashville Law enforcement sources tell @CBSNews leading theory is suspect may have been killed in Nashville explosion. DNA tests on remains found at scene are being conducted to determine if they belong to suspect or someone else + Fed agents searching home person of interest.
— Catherine Herridge (@CBS_Herridge) December 26, 2020
Newsweek reports that the investigators are trying to find the suspect’s mother to conduct DNA tests.
FBI Special Agent in Charge Douglas Korneski earlier said officials had received about 500 tips possibly relating to the explosion.
After visiting the site, Tennessee Governor Bill Lee said it was a “miracle” that no-one had been killed.
He said he had asked President Donald Trump for a federal emergency declaration for his state to aid relief efforts.
What happened in Nashville?
Officers responded to reports of gunshots just before 06:00 local time (12:00 GMT) on 25 December in an area of the city known for its restaurants and nightlife.
Shortly afterwards, they found a camper van broadcasting a warning message to leave the area.
The van exploded a few minutes later, the force of the blast knocking an officer off their feet, police said.
Police have released this image of the van – described by Nashville police as a recreational vehicle (RV) – arriving at the scene early on Friday.
BREAKING: This is the RV that exploded on 2nd Ave N this morning. It arrived on 2nd Ave at 1:22 a.m. Have you seen this vehicle in our area or do you have information about it? Please contact us via Crime Stoppers at 615-742-7463 or online via https://t.co/dVGS7o0m4v. @ATFHQ pic.twitter.com/JNx9sDinAH
The van blew up outside a building belonging to the telecoms giant AT&T, which also occupies an office tower nearby.
Buildings suffered structural damage, windows were blown out, and trees were felled. Videos posted on social media showed water from damaged pipes running down walls as alarms howled in the background.
Police emergency systems were knocked out across Tennessee.
Telephone, internet and fibre optic TV services were also disrupted in Tennessee, Mississippi, Kentucky, Alabama and Georgia, according to telecoms firm AT&T.
Resident Buck McCoy said he had been woken up by the blast. He posted a video on Facebook, showing some of the damage done, with alarms howling in the background.
“All my windows, every single one of them got blown into the next room. If I had been standing there, it would have been horrible,” Mr McCoy told AP. “It felt like a bomb. It was that big.”