It sent his manager Jurgen Klopp sprinting onto the pitch to hug goalkeeper Alisson and the fans into raptures, but was cruel on Everton, who had at times played the more adventurous football in a lively encounter.
The 232nd meeting between the city rivals was heading for a draw when Pickford mishandled a sliced Virgil van Dijk shot that had ballooned high up into the air.
It seemed set to land on top of his net, but the England keeper clawed the ball back down from above his crossbar and spilled it out to Origi.
A late substitute making his first Premier League appearance since August 2017, all the Belgian striker had to do was nod into an empty goal to secure a win that consolidates Liverpool’s second place, two points behind defending champions Manchester City.
In the 87th-minute Origi had missed what looked to be the golden late chance to seal victory when he smashed against the bar from three yards, unable to convert a ball bouncing loose from a corner.
The Toffees remain without a victory in their past 18 meetings with the Reds, and are winless at Anfield this century.
They remain in sixth position in the table, eight points below Tottenham in fifth and Arsenal in fourth.
Chances spurned until late, late drama
The main themes before Pickford’s nightmare moment were fine goalkeeping and repeated wastefulness.
Alisson was forced into two vital first-half stops for the hosts, the first from point-blank range to keep out Andre Gomes’ header, with Joe Gomez clearing the rebound off the line and Gylfi Sigurdsson only able to force the ball onto the post and behind as he followed in.
Then the Brazilian keeper came sprawling off his line to deny Theo Walcott, who found himself clear on goal from Sigurdsson’s masterful through ball, while Pickford expertly blocked Xherdan Shaqiri in a one-on-one shortly after.
Following the break, Mane fired off target twice more from good positions, the first in another one-on-one when his manager already had his fists clenched ready to punch the air in celebration.
‘Completely wrong’ – criticism for Klopp
Klopp would be lucky not to be running past me if I was playing in that game. But that’s the sort of problems it can cause.
I just think it’s completely wrong. You cannot go on to the middle of the pitch, no matter what the circumstances.
There are so many managers that get absolutely hammered but Klopp is very media friendly, everybody seems to love him and he can’t do anything wrong.
Cruel on impressive Everton
There are still positives for Everton to take from this cruel defeat.
Liverpool had only conceded once at home in the league this season, so they are not alone in being unable to breach Alisson’s goal, and Pickford’s mistake is all the more shocking because of his otherwise solid performances for club and country.
Silva, who had won one and drawn one of his previous two meetings with Liverpool as a manager, might have been dreaming of achieving the feat with the outcome still in the balance with minutes to play.
Their most recent victory at Anfield was courtesy of a Kevin Campbell winner in September 1999. They remain winless in 19 trips, but this was a hugely encouraging performance. The result just did not match it.
Klopp’s apology – what the managers said
Liverpool boss Jurgen Klopp:
“First of all I have to apologise for my run. I apologised immediately after to Marco Silva, I didn’t want to be disrespectful.
“My respect to Everton could not be bigger after that game. We knew how strong they were but today they were outstandingly strong and difficult with the way they played.
“The goal was lucky of course but our idea was clear: we wanted to win until the last second. We wanted to show that by bringing strikers on. It was a long and open game. I think we deserved the three points.”
Everton manager Marco Silva:
“It was a tough match and a tough result for us. We don’t deserve to lose. We had the better chances to score but that is football. It is our life. That goal you cannot expect to happen.
“The players understand they deserved something more. We started the match together and that is how we end it. We will be in this way and do everything to win the next match. All the support I can give to Jordan, I will. He is a very good goalkeeper. He did not expect that situation.
“We are improving and we did again this afternoon even if the result wasn’t what we wanted or deserved. I am proud of my players and what they are doing. Nobody in the stadium expected that moment. The way they celebrated it showed to me how difficult it was for them.”
Man of the match – Andre Gomes (Everton)
Liverpool’s defensive mettle – the stats
- Liverpool have conceded just five goals in their first 14 Premier League games this season; only Chelsea in 2008-09 conceded fewer at this stage with four
- Everton’s Theo Walcott has played 395 minutes at Anfield in the Premier League without scoring – the most he has played at any stadium without ever finding the net
- Liverpool’s unbeaten run of 18 matches against Everton in all competitions (W9 D9) is their longest unbeaten run against their rivals
- Liverpool have recorded 11 clean sheets in the Premier League so far in 2018 at Anfield; only in 2002 and 2006 have the Reds kept more (12)
- Liverpool’s Roberto Firmino has failed to score in his past nine Premier League games at Anfield – the Brazilian’s longest drought at home in the competition
Liverpool next play in the Premier League away at 19th-placed Burnley. who are without a win in seven games. That match is on Wednesday at 19:45 GMT.
Everton welcome Newcastle to Goodison Park on the same night at the same time.