Gaza’s health ministry said seven people were injured in the strikes.
“Israel will not tolerate this, I will not tolerate this,” Israeli Prime Minister Benjamin Netanyahu told reporters during a ceremony in Washington at which US President Donald Trump formally recognised Israeli sovereignty over the occupied Golan Heights, which Israel captured from Syria in the 1967 Middle East war.
“Israel is responding forcefully to this wanton aggression,” Mr Netanyahu added.
Mr Trump denounced the attack as “despicable” and said the US “recognises Israel’s absolute right to defend itself”.
What happened on Monday morning?
The Israeli ambulance service treated two women who were moderately wounded and five other people, including an infant, a three-year-old boy and a 12-year-old girl, who had minor wounds.
The house belonged to Robert and Susan Wolf, two British-Israeli dual nationals, who had been at home with their son, daughter-in-law and grandchildren.
“I nearly lost my family. If we had not got to the bomb shelter in time I would now be burying all my family,” Mr Wolf told reporters.
The blast also caused damage to at least one nearby home and several vehicles.
What has Israel struck in response?
Palestinian security sources, media outlets and witnesses said there were strikes across Gaza on Monday evening.
The IDF also said its fighter jets targeted the offices of Hamas’ Internal Security Service, as well as a three-storey building in the Sabra district in eastern Gaza City that served as the “secret headquarters” of Hamas’s General Security Forces, and its General Intelligence and Military Intelligence agencies.
The official Palestinian news agency meanwhile reported that Israeli jets fired missiles at two locations in central Gaza City and in the eastern Shujaiya district.
At 21:00 local time (19:00 GMT), the IDF reported “air-raid sirens sounding across southern Israel”, while a reporter for news agency AFP said they saw “around 10 rockets” fire in quick succession.
Before launching the strikes, the IDF deployed two additional brigades to southern Israel and began what it called a “very limited” call-up of reservists.
Israeli authorities also closed roads near the boundary fence with Gaza, suspended agricultural work in the area, postponed major events in the southern coastal town of Ashkelon, and opened bomb shelters.